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. 2011 Jul;15(5):368-81.
doi: 10.1177/1087054710366421. Epub 2011 Apr 13.

Cerebellar gray matter density in females with ADHD combined type: a cross-sectional voxel-based morphometry study

Luis Guillermo Almeida Montes  1 , Josefina Ricardo-Garcell, Lázaro Barajas De la Torre, Hugo Prado Alcántara, Reyna Beatriz Martínez García, David Avila Acosta, Antonio Fernández Bouzas
Affiliations

Cerebellar gray matter density in females with ADHD combined type: a cross-sectional voxel-based morphometry study

Luis Guillermo Almeida Montes et al. J Atten Disord. 2011 Jul.

Abstract

Background: MRI studies have shown a decreased cerebellum volume in individuals with ADHD. However, most of these studies were conducted with male children, many of whom were medicated with stimulants. As such, unmedicated, non-White girls are underrepresented in such MRI studies.

Objective: The aim of the present study was to compare the density of gray matter (GM) in the cerebellar hemisphere between unmedicated, non-White female children, adolescents, and adults diagnosed with ADHD combined type (ADHD-C) and healthy controls.

Method: MRIs were performed on 11 Hispanic unmedicated ADHD-C children (6-10 years old), 8 Hispanic adolescents (14-17 years old), 10 Hispanic adults (25-35 years old), and the respective healthy controls. Image processing and statistical analyses were performed by Voxel Based Morphometry using the DARTEL algorithm to improve spatial normalization.

Results: Reduced GM density located in the right cerebellar hemisphere was found in female children, adolescents, and adults with ADHD-C.

Conclusions: These findings suggest that there is an anatomical abnormality in the right cerebellar hemisphere in unmedicated Hispanic girls with ADHD-C that is present from childhood to adulthood.

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