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. 2011 Jun;49(6):2304-6.
doi: 10.1128/JCM.00325-11. Epub 2011 Apr 13.

Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment

Marie Desnos-Ollivier  1 , Olivier Moquet, Taieb Chouaki, Anne-Marie Guérin, Françoise Dromer
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Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment

Marie Desnos-Ollivier et al. J Clin Microbiol. 2011 Jun.

Abstract

Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C. lusitaniae isolates was observed during caspofungin treatment. This resistance resulted from missense mutation in the echinocandin target Fks1 gene.

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References

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