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. 2011:2011:326497.
doi: 10.1155/2011/326497. Epub 2010 Dec 15.

Liposomes for use in gene delivery

Daniel A Balazs  1 , Wt Godbey
Affiliations

Liposomes for use in gene delivery

Daniel A Balazs et al. J Drug Deliv. 2011.

Abstract

Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.

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Figures

Figure 1
Figure 1
Certain amphipathic lipid molecules in aqueous solution spontaneously form leaflets, then bilayer membranes, and eventually liposomes.
Figure 2
Figure 2
Structures predicted by the packing parameter P.
Figure 3
Figure 3
The structure of DOTMA.
Figure 4
Figure 4
The structure of DOTAP.
Figure 5
Figure 5
The structure of DC-Chol.
Figure 6
Figure 6
The structure of DOSPA.
Figure 7
Figure 7
The structure of DOGS.
Figure 8
Figure 8
The structures of two neutral lipids. (a) DOPE (b) DOPC.
Figure 9
Figure 9
Anionic Lipids. (a) Phosphatidic acid (pH = 7). (b) Phosphatidylglycerol. (c) Phosphatidylserine.
See this image and copyright information in PMC

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