[Effect of single exposure to the carcinogen 4-dimethylaminoazobenzene on several properties of rat liver mitochondria]
[Article in
Russian]
- PMID: 214910
Item in Clipboard
[Effect of single exposure to the carcinogen 4-dimethylaminoazobenzene on several properties of rat liver mitochondria]
[Article in
Russian]
Tsitologiia.
1978 Oct.
Abstract
The hepatospecific carcinogen 4-dimethylaminoazobenzene (DAB), applied as a single interperitoneal injection, induced no changes in the activity of mitochondrial and cytoplasmic malate-dehydrogenase in the rat liver. The same carcinogen and non-carcinogenic isomer 4-diethylaminoazobenzene brought about decreased activity of cytochromeoxidase in isolated rat liver mitochondria. During 18 days after a single interperitoneal injection of DAB the swelling-contraction properties of isolated liver mitochondria were seen altered in the presence of succinate and ATP whereas DAB exerted no influence on mitochondria from the kidney, which organ is not a target-tissue for carcinogenic action.
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