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. 1990 Sep;36(3):219-26.
doi: 10.1111/j.1399-3011.1990.tb00970.x.

A synthetic protein corresponding to the entire vpr gene product from the human immunodeficiency virus HIV-1 is recognized by antibodies from HIV-infected patients

H Gras-Masse  1 , J C Ameisen, C Boutillon, J C Gesquière, S Vian, J L Neyrinck, H Drobecq, A Capron, A Tartar
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A synthetic protein corresponding to the entire vpr gene product from the human immunodeficiency virus HIV-1 is recognized by antibodies from HIV-infected patients

H Gras-Masse et al. Int J Pept Protein Res. 1990 Sep.

Abstract

The 95 amino acid-protein encoded by the non-structural vpr gene of the human immunodeficiency virus type 1 (LAV-1BRU isolate) was chemically synthesized by solid phase methodology. The synthetic vpr protein was characterized by amino acid analysis, sequence analysis, RP-HPLC, and urea-SDS PAGE. Using a radioimmunoassay, antibodies to the synthetic protein were detected in sera of 25% of HIV 1-seropositive patients tested. Western blot analysis suggested that the antibodies preferentially recognize the dimeric form of vpr.

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