doi: 10.1021/ol2007154.
Epub 2011 Apr 14.
Electrophile-driven regioselective synthesis of functionalized quinolines
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- PMID: 21491872
- DOI: 10.1021/ol2007154
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Electrophile-driven regioselective synthesis of functionalized quinolines
Org Lett.
.
Abstract
Highly substituted 3-iodoquinolines bearing different alkyl and aryl moieties can be synthesized in moderate to excellent yields (up to 99%) by 6-endo-dig iodocyclization of 2-tosylaminophenylprop-1-yn-3-ols with molecular iodine (I(2)) under mild conditions. The cyclization is highly regioselective and the resulting 3-iodoquinolines can be further functionalized by various coupling reactions.
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