[Hyperlipemia and lipoprotein blood spectrum of rabbits of different age with administration of cholesterol]

Abstract

Hyperlipemia developing in impuberal, young and old rabbits with administered cholesterol is characterized by a considerable prevailence of the cholesterol level over the triglyceride one. The degree of shifts in lipids depends on the age, it is most pronounced in old animals and the least pronounced in impuberal ones. The amount of blood serum cholesterol bound with lipoproteids of high density lowers and most considerably in old rabbits. Separation of blood serum lipoproteids by electrophoresis in polyacrylamide gel detects in rabbits with hyperlipemia a sharp decrease as compared to the norm in the intensity of alpha-lipoproteids disc. This decrease is most pronounced in animals of older age groups. The presence of the intermediate fraction between pre-beta- and beta-lipoproteids is also found in the same animal by the separation especially often in old animals.