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Review
. 2011 Oct;46(5):1534-61.
doi: 10.1111/j.1475-6773.2011.01263.x. Epub 2011 Apr 14.

The cost-effectiveness of three screening alternatives for people with diabetes with no or early diabetic retinopathy

David B Rein  1 , John S Wittenborn, Xinzhi Zhang, Benjamin A Allaire, Michael S Song, Ronald Klein, Jinan B Saaddine; Vision Cost-Effectiveness Study Group
Affiliations
Review

The cost-effectiveness of three screening alternatives for people with diabetes with no or early diabetic retinopathy

David B Rein et al. Health Serv Res. 2011 Oct.

Abstract

Objective: To determine whether biennial eye evaluation or telemedicine screening are cost-effective alternatives to current recommendations for the estimated 10 million people aged 30-84 with diabetes but no or minimal diabetic retinopathy.

Data sources: United Kingdom Prospective Diabetes Study, National Health and Nutrition Examination Survey, American Academy of Ophthalmology Preferred Practice Patterns, Medicare Payment Schedule.

Study design: Cost-effectiveness Monte Carlo simulation.

Data collection/extraction methods: Literature review, analysis of existing surveys.

Principal findings: Biennial eye evaluation was the most cost-effective treatment option when the ability to detect other eye conditions was included in the model. Telemedicine was most cost-effective when other eye conditions were not considered or when telemedicine was assumed to detect refractive error. The current annual eye evaluation recommendation was costly compared with either treatment alternative. Self-referral was most cost-effective up to a willingness to pay (WTP) of U.S.$37,600, with either biennial or annual evaluation most cost-effective at higher WTP levels.

Conclusions: Annual eye evaluations are costly and add little benefit compared with either plausible alternative. More research on the ability of telemedicine to detect other eye conditions is needed to determine whether it is more cost-effective than biennial eye evaluation.

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Figures

Figure 1
Figure 1
Diagram of the Diabetic Retinopathy Model Disease Stages and Transitions Note. Diabetic retinopathy (DR) severity is classified jointly across both eyes as 10 = absent; 20 = microaneurisms (MA) only with other lesions absent; 35 = mild nonproliferative DR (NPDR) defined as MA plus retinal hemorrhages, and/or hard exudates, and/or cotton wool spots; and 43 = moderate NPDR defined as mild NPDR plus either extensive or severe hemorrhages and MA (HMA) or intraretinal microvascular abnormalities (IRMA) present, in the absence of CSME. UKPDS function refers to the mathematical equation through which patients progress from DR states of 35/20 or higher to vision-threatening disease in one or both eyes. CSME, clinically significant macular edema; HR-PDR, high-risk proliferative diabetic retinopathy; Non-HR-PDR, non-high-risk proliferative diabetic retinopathy; UKPDS, United Kingdom Prospective Diabetes Study.
Figure 2
Figure 2
Probability Each Intervention Is the Most Cost-Effective Given a Range of Values for the Willingness to Pay per QALY Gained
See this image and copyright information in PMC

References

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