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. 2011 Jun;204(6 Suppl 1):S141-8.
doi: 10.1016/j.ajog.2011.02.042. Epub 2011 Feb 23.

Impact of maternal immunization on influenza hospitalizations in infants

Katherine A Poehling  1 , Peter G Szilagyi, Mary A Staat, Beverly M Snively, Daniel C Payne, Carolyn B Bridges, Susan Y Chu, Laney S Light, Mila M Prill, Lyn Finelli, Marie R Griffin, Kathryn M Edwards; New Vaccine Surveillance Network
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Impact of maternal immunization on influenza hospitalizations in infants

Katherine A Poehling et al. Am J Obstet Gynecol. 2011 Jun.

Abstract

We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.

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Figures

Figure 1
Figure 1
Study population
Figure 2
Figure 2
The odds ratio and 95% confidence interval for the protection provided by influenza vaccination during pregnancy on laboratory-confirmed influenza hospitalizations among infants for unadjusted and adjusted models. Model 1 includes study year, site, race and ethnicity, gender, age group and timing in influenza season. Model 2 includes model 1, prematurity and high-risk medical conditions. Model 3 includes model 1, smoke exposure, daycare, any breast feeding, siblings and insurance status.
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