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. 2011 Jun;20(6):1064-77.
doi: 10.1158/1055-9965.EPI-11-0038. Epub 2011 Apr 14.

Lymphoid malignancies in U.S. Asians: incidence rate differences by birthplace and acculturation

Christina A Clarke  1 , Sally L Glaser, Scarlett L Gomez, Sophia S Wang, Theresa H Keegan, Juan Yang, Ellen T Chang
Affiliations

Lymphoid malignancies in U.S. Asians: incidence rate differences by birthplace and acculturation

Christina A Clarke et al. Cancer Epidemiol Biomarkers Prev. 2011 Jun.

Abstract

Background: Malignancies of the lymphoid cells, including non-Hodgkin lymphomas (NHL), HL, and multiple myeloma, occur at much lower rates in Asians than other racial/ethnic groups in the United States. It remains unclear whether these deficits are explained by genetic or environmental factors. To better understand environmental contributions, we examined incidence patterns of lymphoid malignancies among populations characterized by ethnicity, birthplace, and residential neighborhood socioeconomic status (SES) and ethnic enclave status.

Methods: We obtained data about all Asian patients diagnosed with lymphoid malignancies between 1988 and 2004 from the California Cancer Registry and neighborhood characteristics from U.S. Census data.

Results: Although incidence rates of most lymphoid malignancies were lower among Asian than white populations, only follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and nodular sclerosis (NS) HL rates were statistically significantly lower among foreign-born than U.S.-born Asians with incidence rate ratios ranging from 0.34 to 0.87. Rates of CLL/SLL and NS HL were also lower among Asian women living in ethnic enclaves or lower SES neighborhoods than those living elsewhere.

Conclusions: These observations support strong roles of environmental factors in the causation of FL, CLL/SLL, and NS HL.

Impact: Studying specific lymphoid malignancies in U.S. Asians may provide valuable insight toward understanding their environmental causes.

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Conflict of interest statement

No authors report any financial conflict of interest.

References

    1. Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS. Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood. 2006;107:265–76. - PMC - PubMed
    1. Carreon JD, Morton LM, Devesa SS, Clarke CA, Gomez SL, Glaser SL, et al. Incidence of lymphoid neoplasms by subtype among six Asian ethnic groups in the United States, 1996–2004. Cancer Causes Control. 2008;19:1171–81. - PMC - PubMed
    1. Gomez SL, Glaser SL. Quality of birthplace information obtained from death certificates for Hispanics, Asians, and Pacific Islanders. Ethn Dis. 2004;14:292–5. - PubMed
    1. Gomez SL, Glaser SL. Quality of cancer registry birthplace data for Hispanics living in the United States. Cancer Causes & Control. 2005;16:713–23. - PubMed
    1. Gomez SL, Glaser SL, Kelsey JL, Lee MM. Bias in completeness of birthplace data for Asian groups in a population-based cancer registry (United States) Cancer Causes Control. 2004;15:243–53. - PubMed

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