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Comment
. 2011 Apr 15;108(8):903-4.
doi: 10.1161/RES.0b013e31821bc2d8.

Telomeres and mitochondrial function

Toren Finkel  1
Affiliations
Comment

Telomeres and mitochondrial function

Toren Finkel. Circ Res. .
No abstract available

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Figures

Figure
Figure
A connection between telomere shortening in the nucleus and mitochondrial dysfunction. Key to this connection is the activation of the tumor suppressor, p53, that acts as a transcriptional repressor of the PGC-1 family of transcriptional coactivators. PGC-1α/β are, in turn, important regulators of mitochondrial biogenesis. See text for additional details.
See this image and copyright information in PMC

Comment on

  • Telomere dysfunction induces metabolic and mitochondrial compromise.
    Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Sahin E, et al. Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9. Nature. 2011. PMID: 21307849 Free PMC article.

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