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Case Reports
. 2011 Mar;17(1):76-9.
doi: 10.3350/kjhep.2011.17.1.76.

IgG4-related sclerosing cholangitis: liver biopsy findings

Han Suk Ryu  1 , Haeryoung Kim
Affiliations
Case Reports

IgG4-related sclerosing cholangitis: liver biopsy findings

Han Suk Ryu et al. Korean J Hepatol. 2011 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Histologic features of the biopsied liver. (A, B) Lymphoplasmacytic and eosinophilic infiltration in the portal tracts (A: H&E, ×200; B: H&E, ×100). The inflammatory cell infiltrates are centered predominantly around the portal veins (arrows), while the hepatic artery (white arrowhead) and bile duct epithelia (black arrowhead) are relatively intact without degenerative changes. The portal tracts are mildly fibrotic, without an 'onion-skin' appearance. Immunohistochemical stain for IgG4 reveals several scattered IgG4-positive plasma cells in the portal tracts (C: IgG4 immunostaining, ×400).
Figure 2
Figure 2
Histologic features of the pancreas (A-C). Diffuse lymphoplasmacytic infiltration of the pancreatic lobules and periductal areas with marked septal fibrosis is seen (A: H&E, ×40). The inflammatory cells infiltrate the periductal areas without destruction of the ductal epithelia (B: H&E, ×100). Obliterative phlebitis is frequently seen (arrow), while ductal epithelia and arteries are spared. (C: Elastic van Gieson, ×200). Abundant IgG4-positive plasma cells are seen in the pancreatic parenchyma (D: IgG4 immunostaining, ×400).
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