Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Mar;17(1):76-9.
doi: 10.3350/kjhep.2011.17.1.76.

IgG4-related sclerosing cholangitis: liver biopsy findings

Han Suk Ryu  1 , Haeryoung Kim
Affiliations
Case Reports

IgG4-related sclerosing cholangitis: liver biopsy findings

Han Suk Ryu et al. Korean J Hepatol. 2011 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Histologic features of the biopsied liver. (A, B) Lymphoplasmacytic and eosinophilic infiltration in the portal tracts (A: H&E, ×200; B: H&E, ×100). The inflammatory cell infiltrates are centered predominantly around the portal veins (arrows), while the hepatic artery (white arrowhead) and bile duct epithelia (black arrowhead) are relatively intact without degenerative changes. The portal tracts are mildly fibrotic, without an 'onion-skin' appearance. Immunohistochemical stain for IgG4 reveals several scattered IgG4-positive plasma cells in the portal tracts (C: IgG4 immunostaining, ×400).
Figure 2
Figure 2
Histologic features of the pancreas (A-C). Diffuse lymphoplasmacytic infiltration of the pancreatic lobules and periductal areas with marked septal fibrosis is seen (A: H&E, ×40). The inflammatory cells infiltrate the periductal areas without destruction of the ductal epithelia (B: H&E, ×100). Obliterative phlebitis is frequently seen (arrow), while ductal epithelia and arteries are spared. (C: Elastic van Gieson, ×200). Abundant IgG4-positive plasma cells are seen in the pancreatic parenchyma (D: IgG4 immunostaining, ×400).
See this image and copyright information in PMC

References

    1. Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38:982–984. - PubMed
    1. Nakazawa T, Ohara H, Sano H, Ando T, Aoki S, Kobayashi S, et al. Clinical differences between primary sclerosing cholangitis and sclerosing cholangitis with autoimmune pancreatitis. Pancreas. 2005;30:20–25. - PubMed
    1. Nakazawa T, Ando T, Hayashi K, Naitoh I, Ohara H, Joh T. Diagnostic procedures for IgG4-related sclerosing cholangitis. J Hepatobiliary Pancreat Sci. 2010 Sep 02; [Epub ahead of print] - PubMed
    1. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732–738. - PubMed
    1. Björnsson E, Chari ST, Smyrk TC, Lindor K. Immunoglobulin G4 associated cholangitis: description of an emerging clinical entity based on review of the literature. Hepatology. 2007;45:1547–1554. - PubMed

Publication types

Substances

LinkOut - more resources