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. 2010 Jul;23(7):677-684.
doi: 10.1002/poc.1620.

An Analysis of All the Relevant Facts and Arguments Indicates that Enzyme Catalysis Does Not Involve Large Contributions from Nuclear Tunneling

Shina C L Kamerlin  1 , Arieh Warshel
Affiliations

An Analysis of All the Relevant Facts and Arguments Indicates that Enzyme Catalysis Does Not Involve Large Contributions from Nuclear Tunneling

Shina C L Kamerlin et al. J Phys Org Chem. 2010 Jul.
No abstract available

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Figures

Figure 1
Figure 1
A comparison between (a) the calculated and observed primary deuterium kinetic isotope effects in different enzymes and (b) the calculated primary deuterium kinetic isotope effects in these enzymes and in the relevant reference reactions in water. The data is originally presented in Ref. [17] (and references therein).
Figure 2
Figure 2
The catalytic (anticatalytic effect) of the donor-acceptor distance dependence of the NQM effects in hydride transfer reactions. The traditional idea that the NQM effects increase upon compression of the donor-acceptor distance is described in Fig. 2(a). This view assumes that enzyme catalysis involves an increase in tunneling due to the compression effects. On the other hand, as shown here, the NQM effects actually increase when the donor-acceptor distance decreases (Fig. 2(b)) and thus it is hard to rationalize a relationship between NQM effects and catalysis. The figure is taken from Ref.[32].
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References

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    1. Borman S. Chem. Eng. News. 2004;82:35.
    1. Warshel A, Sharma PK, Kato M, Xiang Y, Liu H, Olsson MH. Chem. Rev. 2006;106:3210. - PubMed
    1. Warshel A, Sharma PK, Kato M, Parson W. BBA. 2006;1764:1647. - PubMed

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