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. 1998 Jan;40(1):60-6.

Active platelet 5-ht uptake in depressives treated with impramine and ect

P K Dalal  1 , N Lal, J K Trivedi, P K Seth, A K Agarwal, A Khalid
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Active platelet 5-ht uptake in depressives treated with impramine and ect

P K Dalal et al. Indian J Psychiatry. 1998 Jan.

Abstract

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.

Keywords: Active platelet 5-HT uptake; ECT; imipramine; major depression.

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