Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Jan;40(1):60-6.

Active platelet 5-ht uptake in depressives treated with impramine and ect

P K Dalal  1 , N Lal, J K Trivedi, P K Seth, A K Agarwal, A Khalid
Affiliations

Active platelet 5-ht uptake in depressives treated with impramine and ect

P K Dalal et al. Indian J Psychiatry. 1998 Jan.

Abstract

Several studies have reported decreased platelet 5-HT uptake in patients of major depression. The present study was undertaken with the aim to study the active platelet 5-HT uptake in depressed patients and effect of treatment with imipramine/ECT on platelet 5-HT uptake in these patients. 30 patients of major depression and equal number of age and sex-matched controls were included in the study. The depressives received imipramine (N=15) or ECT (N=15). Pretreatment active platelet 5-HT uptake was lower in depressives. Treatment with imipramine resulted in significant decrease in 5-HT uptake while with ECT there was significant increase. The serotonergic mechanisms are discussed.

Keywords: Active platelet 5-HT uptake; ECT; imipramine; major depression.

PubMed Disclaimer

References

    1. Clin Chem. 1994 Feb;40(2):288-95 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):224-5 - PubMed
    1. Life Sci. 1967 Aug 1;6(15):1653-63 - PubMed
    1. Br J Psychiatry. 1992 Feb;160:223-9 - PubMed
    1. Br J Clin Pharmacol. 1976 Aug;3(4):649-53 - PubMed