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. 1998 Jan;40(1):70-2.

Clozapine-induced agranulocytosis and use of g-csf

T N Srinivasan  1 , K Thomas
Affiliations

Clozapine-induced agranulocytosis and use of g-csf

T N Srinivasan et al. Indian J Psychiatry. 1998 Jan.

Abstract

Use of clozapine is attended with the serious though rare risk of agranulocytosis. Clozapineinduced agranulocytosis is reversible with the use of cytokines like granulocyte-colony stimulating factor (G-CSF). Reports of the haematological complication of clozapine have not been forthcoming from India though it has been in use for nearly three years. This report is on an young patient who developed total absence of granulocytes during the 4th month of treatment who was successfully treated with G-CSF.

Keywords: Clozapine; G-CSF; agranulocytosis.

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