Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Sep 1;104(3):323-32.
doi: 10.1002/jso.21943. Epub 2011 Apr 14.

The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

Boudewijn E Schaafsma  1 , J Sven D Mieog, Merlijn Hutteman, Joost R van der Vorst, Peter J K Kuppen, Clemens W G M Löwik, John V Frangioni, Cornelis J H van de Velde, Alexander L Vahrmeijer
Affiliations
Review

The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

Boudewijn E Schaafsma et al. J Surg Oncol. .

Abstract

Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT: John V. Frangioni: All FLARE technology is owned by Beth Israel Deaconess Medical Center, a teaching hospital of Harvard Medical School. As inventor, Dr. Frangioni may someday receive royalties if products are commercialized. Dr. Frangioni is the founder and unpaid director of The FLARE Foundation, a non-profit organization focused on promoting the dissemination of medical imaging technology for research and clinical use.

Figures

Fig. 1
Fig. 1
Fig. 2
Fig. 2
Fig. 3
Fig. 3
Fig. 4
Fig. 4
See this image and copyright information in PMC

References

    1. Frangioni JV. New technologies for human cancer imaging. J Clin Oncol. 2008;26:4012–4021. - PMC - PubMed
    1. Handa T, Katare RG, Nishimori H, et al. New device for intraoperative graft assessment: HyperEye charge-coupled device camera system. Gen Thorac Cardiovasc Surg. 2010;58:68–77. - PubMed
    1. Troyan SL, Kianzad V, Gibbs-Strauss SL, et al. The FLARE Intraoperative Near-Infrared Fluorescence Imaging System: A First-in-Human Clinical Trial in Breast Cancer Sentinel Lymph Node Mapping. Ann Surg Oncol. 2009;16:2943–2952. - PMC - PubMed
    1. Crane LM, Themelis G, Pleijhuis RG, et al. Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept. Mol Imaging Biol. 2010 - PMC - PubMed
    1. Matsui A, Tanaka E, Choi HS, et al. Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents. Surgery. 2010;148:87–95. - PMC - PubMed

Publication types