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Review
. 2011 Sep 1;104(3):323-32.
doi: 10.1002/jso.21943. Epub 2011 Apr 14.

The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

Boudewijn E Schaafsma  1 , J Sven D Mieog, Merlijn Hutteman, Joost R van der Vorst, Peter J K Kuppen, Clemens W G M Löwik, John V Frangioni, Cornelis J H van de Velde, Alexander L Vahrmeijer
Affiliations
Review

The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

Boudewijn E Schaafsma et al. J Surg Oncol. .

Abstract

Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT: John V. Frangioni: All FLARE technology is owned by Beth Israel Deaconess Medical Center, a teaching hospital of Harvard Medical School. As inventor, Dr. Frangioni may someday receive royalties if products are commercialized. Dr. Frangioni is the founder and unpaid director of The FLARE Foundation, a non-profit organization focused on promoting the dissemination of medical imaging technology for research and clinical use.

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