Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1990 Dec 20;37(6):951-9.
doi: 10.1016/0960-0760(90)90449-u.

Orchidectomy versus Zoladex plus Eulexin in patients with metastatic prostate cancer (EORTC 30853)

L Denis  1 , M Robinson, C Mahler, P Smith, F Keuppens, J L De Moura, A Bono, D Newling, R Sylvester, M De Pauw, et al.
Affiliations
Clinical Trial

Orchidectomy versus Zoladex plus Eulexin in patients with metastatic prostate cancer (EORTC 30853)

L Denis et al. J Steroid Biochem Mol Biol. .

Abstract

A total of 327 patients with metastatic prostate cancer have been randomized to either orchidectomy or treatment with goserelin (Zoladez) 3.6 mg depot preparation combined with flutamide (Eulexin) 250 mg t.i.d. in a phase III study (EORTC 30853). A small but statistically significant difference in time to subjective and objective progression of disease was found in favour of the combination treatment. However, time from objective progression to death was longer in the group initially allocated to orchidectomy. Thus no difference was found in overall survival between the two treatment groups. The clinical significance of these differences requires further follow up and analysis.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources