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. 2011 Apr;51(4):894-900.
doi: 10.1111/j.1537-2995.2011.03103.x.

Properties of stored red blood cells: understanding immune and vascular reactivity

Philip C Spinella  1 , Rosemary L Sparrow, John R Hess, Philip J Norris
Affiliations

Properties of stored red blood cells: understanding immune and vascular reactivity

Philip C Spinella et al. Transfusion. 2011 Apr.
No abstract available

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Figures

Figure 1
Figure 1. Biological pathways and potential causes of a RBC storage lesion
The figure illustrates that there are many potential mechanisms of a potential storage lesion, impacting overlapping pathways of oxygen delivery, RBC rheology and physiology, and immune modulation.
See this image and copyright information in PMC

References

    1. Bosman GJ, Lasonder E, Luten M, et al. The proteome of red cell membranes and vesicles during storage in blood bank conditions. Transfusion. 2008;48:827–35. - PubMed
    1. Silliman CC, Clay KL, Thurman GW, et al. Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase. J Lab Clin Med. 1994;124:684–94. - PMC - PubMed
    1. Anniss AM, Sparrow RL. Storage duration and white blood cell content of red blood cell (RBC) products increases adhesion of stored RBCs to endothelium under flow conditions. Transfusion. 2006;46:1561–7. - PubMed
    1. McFaul SJ, Bowman PD, Villa VM, et al. Hemoglobin stimulates mononuclear leukocytes to release interleukin-8 and tumor necrosis factor alpha. Blood. 1994;84:3175–81. - PubMed
    1. Pati S, Matijevic N, Doursout MF, et al. Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw. J Trauma. 2010;69(Suppl 1):S55–63. - PMC - PubMed

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