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. 2011 Dec;12(8):690-5.
doi: 10.1111/j.1399-5448.2011.00764.x. Epub 2011 Apr 17.

The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring

Roy Beck  1 , Michael Steffes, Dongyuan Xing, Katrina Ruedy, Nelly Mauras, Darrell M Wilson, Craig Kollman; Diabetes Research in Children Network (DirecNet) Study Group
Collaborators, Affiliations

The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring

Roy Beck et al. Pediatr Diabetes. 2011 Dec.

Abstract

Objectives: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes.

Methods: In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21).

Results: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50-0.60).

Conclusion: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.

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Figures

Figure 1
Figure 1. 1,5 AG versus HbA1c (N=26)
Below is the scatterplot of 1,5-AG versus HbA1c. The analysis included 26 subjects who had both 1,5-AG and HbA1c measures.
Figure 2
Figure 2. Hyperglycemic AUC-180 versus 1,5 AG (N=21)
Below is the scatterplot of Hyperglycemic AUC −180 for glucose above 180 mg/dL versus 1,5-AG with different symbols for subjects with HbA1c ≤8.0% and >8.0%. The analysis included 21 subjects who had both lab measures and CGM data.
See this image and copyright information in PMC

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