Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun;185(6):2050-5.
doi: 10.1016/j.juro.2011.02.051. Epub 2011 Apr 15.

The impact of germline BHD mutation on histological concordance and clinical treatment of patients with bilateral renal masses and known unilateral oncocytoma

Ronald S Boris  1 , Jihane Benhammou, Maria Merino, Peter A Pinto, W Marston Linehan, Gennady Bratslavsky
Affiliations

The impact of germline BHD mutation on histological concordance and clinical treatment of patients with bilateral renal masses and known unilateral oncocytoma

Ronald S Boris et al. J Urol. 2011 Jun.

Abstract

Purpose: Managing oncocytoma in the setting of bilateral renal masses is a challenging scenario. Nevertheless, to our knowledge the pathological concordance of an oncocytic neoplasm in 1 kidney with tumors in the contralateral kidney is not known. We evaluated the influence of germline Birt-Hogg-Dubé mutation on concordance rates to assist in managing these cases.

Materials and methods: We reviewed the records of patients at the National Institutes of Health between 1983 and 2009 who had bilateral renal masses, known pathology bilaterally and oncocytoma or an oncocytic neoplasm in at least 1 kidney. Oncocytoma or an oncocytic neoplasm in 2 renal units was considered concordant. Demographic, pathological and clinical data were collected.

Results: The population consisted of 40 patients, including 23 with and 17 without a diagnosis of Birt-Hogg-Dubé syndrome. Patients with the syndrome were younger (p <0.01) but there were no other differences between the 2 groups. However, patients with the syndrome had statistically lower histological concordance between bilateral masses than patients without the diagnosis (Fisher's exact test p <0.01). Also, the 8 patients without Birt-Hogg-Dubé syndrome who had multifocal renal masses showed 100% oncocytoma concordance between renal units.

Conclusions: Of patients with bilateral renal masses those with Birt-Hogg-Dubé syndrome have significantly lower histological concordance than those without the syndrome. Patients with Birt-Hogg-Dubé syndrome should be monitored and treated differently than those without detected genetic mutations, especially patients with multifocal oncocytomas. Genetic testing for Birt-Hogg-Dubé should be considered in the treatment algorithm of patients with bilateral renal masses and known oncocytoma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Treatment management algorithm for patients with bilateral renal masses and oncocytoma/oncocytic tumor on one side.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Wiklund F, Tretli S, Choueiri TK, et al. Risk of bilateral renal cell cancer. J Clin Oncol. 2009;27:3737. - PubMed
    1. Blute ML, Itano NB, Cheville JC, et al. The effect of bilaterality, pathological features and surgical outcome in nonhereditary renal cell carcinoma. J Urol. 2003;169:1276. - PubMed
    1. Richstone L, Scherr DS, Reuter VR, et al. Multifocal renal cortical tumors: frequency, associated clinicopathological features and impact on survival. J Urol. 2004;171:615. - PubMed
    1. Linehan WM. Genetic basis of bilateral renal cancer: implications for evaluation and management. J Clin Oncol. 2009;27:3731. - PMC - PubMed
    1. Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol. 2003;170:2163. - PubMed

Publication types

MeSH terms