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Review
. 2011 Aug;22(6):566-71.
doi: 10.1016/j.semcdb.2011.03.013. Epub 2011 Apr 7.

The sister bonding of duplicated chromosomes

Hui Zou  1
Affiliations
Review

The sister bonding of duplicated chromosomes

Hui Zou. Semin Cell Dev Biol. 2011 Aug.

Abstract

Sister chromatid cohesion and separation are two fundamental chromosome dynamics that are essential to equal chromosome segregation during cell proliferation. In this review, I will discuss the major steps that regulate these dynamics during mitosis, with an emphasis on vertebrate cells. The implications of these machineries outside of sister chromatid cohesion and separation are also discussed.

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Figures

Fig. 1
Fig. 1
Cohesin structures and key posttranslational modifications. The red circle and box are the hinge domains and head domains of SMC1/3, respectively. Acetylations of SMC3 by ESCO1/2 and cleavages of SCC1 by separase are also indicated.
Fig. 2
Fig. 2
Regulations of sister chromatid cohesion and separation in various stages of the cell cycle. Key regulators are indicated at each transition.
See this image and copyright information in PMC

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References

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