Pain may predict poor prognosis in patients with oral squamous cell carcinoma
- PMID: 21497734
- DOI: 10.1016/j.tripleo.2010.11.033
Pain may predict poor prognosis in patients with oral squamous cell carcinoma
Abstract
Objective: We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC.
Study design: We evaluated the relationships between overall survival rates and clinicopathologic variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC.
Results: Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the overall survival rates of patients with spontaneous pain was significantly lower than those of patients without pain (P = .002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of overall survival rates.
Conclusions: This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
Copyright © 2011 Mosby, Inc. All rights reserved.
Comment in
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Should pain be used as predictor of prognosis in oral squamous cell carcinomas?Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Mar;113(3):423; author reply 424. doi: 10.1016/j.oooo.2011.08.001. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012. PMID: 22669150 No abstract available.
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