Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May;111(5):587-92.
doi: 10.1016/j.tripleo.2010.11.033.

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Jun Sato  1 , Yutaka Yamazaki, Akira Satoh, Makiko Onodera-Kyan, Takahiro Abe, Takehiko Satoh, Ken-ichi Notani, Yoshimasa Kitagawa
Affiliations
Free article

Pain may predict poor prognosis in patients with oral squamous cell carcinoma

Jun Sato et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May.
Free article

Abstract

Objective: We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC.

Study design: We evaluated the relationships between overall survival rates and clinicopathologic variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC.

Results: Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the overall survival rates of patients with spontaneous pain was significantly lower than those of patients without pain (P = .002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of overall survival rates.

Conclusions: This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.

PubMed Disclaimer

Comment in

MeSH terms