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Comment
. 2011 Apr 19;20(4):411-2.
doi: 10.1016/j.devcel.2011.04.002.

Removing the brakes on cell identity

Ildem Akerman  1 , Joris van Arensbergen, Jorge Ferrer
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Free article
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Removing the brakes on cell identity

Ildem Akerman et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Dhawan et al. (2011) show that deletion of the Dnmt1 DNA methyltransferase gene in pancreatic insulin-producing cells makes these cells convert into glucagon-producing cells. This suggests that manipulation of a general epigenetic mechanism may be used to redirect cell fates.

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