Scatter factor regulates vascular endothelial cell motility
- PMID: 2149835
- DOI: 10.3109/07357909009018936
Scatter factor regulates vascular endothelial cell motility
Abstract
Scatter factors (SFs) are mesenchymal cell-derived cytokines which stimulate epithelial motility. SF purified from ras-transformed 3T3 cell supernatants markedly stimulated vascular endothelial cell migration at less than 100 pM. Preliminary studies suggest endothelial lines with cobblestone (epithelioid) morphology respond to SF, while those lines with elongated cells do not respond. SFs may play roles in development and tissue repair.
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