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. 2011 Apr 27;52(17):2041-2043.
doi: 10.1016/j.tetlet.2010.09.059.

Total synthesis and biological evaluation of marinopyrrole A and analogues

K C Nicolaou  1 , Nicholas L Simmons, Jason S Chen, Nina M Haste, Victor Nizet
Affiliations

Total synthesis and biological evaluation of marinopyrrole A and analogues

K C Nicolaou et al. Tetrahedron Lett. .

Abstract

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

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Figures

Figure 1
Figure 1
Marinopyrroles A (1) and B (2).
Scheme 1
Scheme 1
Synthesis of marinopyrrole A [(+)-1 and (−)-1].
Scheme 2
Scheme 2
Synthesis of marinopyrrole A analogues 11–16.
See this image and copyright information in PMC

References

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