Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jul;49(7):723-32.
doi: 10.1007/s11517-011-0776-5. Epub 2011 Apr 16.

Cardiac regeneration: different cells same goal

Phil Barnett  1 , Maurice J B van den Hoff
Affiliations
Review

Cardiac regeneration: different cells same goal

Phil Barnett et al. Med Biol Eng Comput. 2011 Jul.

Abstract

Cardiovascular diseases are the leading cause of mortality, morbidity, hospitalization and impaired quality of life. In most, if not all, pathologic cardiac ischemia ensues triggering a succession of events leading to massive death of cardiomyocytes, fibroblast and extracellular matrix accumulation, cardiomyocyte hypertrophy which culminates in heart failure and eventually death. Though current pharmacological treatment is able to delay the succession of events and as a consequence the development of heart failure, the only currently available and effective treatment of end-stage heart failure is heart transplantation. However, donor heart availability and immunorejection upon transplantation seriously limit the applicability. Cardiac regeneration could provide a solution, making real a dream of both scientist and clinician in the previous century and ending an ongoing challenge for this century. In this review, we present a basic overview of the various cell types that have been used in both the clinical and research setting with respect to myocardial differentiation.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Annual publication frequency within the field of stem cells and cardiac regeneration
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, et al. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med. 2007;167:989–997. doi: 10.1001/archinte.167.10.989. - DOI - PubMed
    1. Alper J. Geron gets green light for human trial of ES cell-derived product. Nat Biotech. 2009;27:213–214. doi: 10.1038/nbt0309-213a. - DOI - PubMed
    1. Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewnthal R, Trakhtenbrot L, et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med. 2009;6:e1000029. doi: 10.1371/journal.pmed.1000029. - DOI - PMC - PubMed
    1. Andrews PW, Banting GS, Damjanov I, Arnaud D, Avner P. Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. Hyrbidoma. 1984;3:347–361. - PubMed
    1. Assmus B, Rolf A, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, et al. Clinical outcome 2 years after intracoronary administration of bone Marrow-derived progenitor cells in acute myocardial infarction. Circ Heart Fail. 2010;3:89–96. doi: 10.1161/CIRCHEARTFAILURE.108.843243. - DOI - PubMed

MeSH terms