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. 2011 Mar 31:5:32.
doi: 10.3389/fnhum.2011.00032. eCollection 2011.

The dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory

Deanna L Wallace  1 , Jason J Vytlacil, Emi M Nomura, Sasha E B Gibbs, Mark D'Esposito
Affiliations

The dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory

Deanna L Wallace et al. Front Hum Neurosci. .

Abstract

We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal-striatal connectivity during a working memory task. After dopaminergic augmentation, frontal-striatal connectivity in low working memory capacity individuals increases, corresponding with behavioral improvement whereas decreases in connectivity in high working memory capacity individuals are associated with poorer behavioral performance. These findings corroborate an inverted U-shape response of dopamine function in behavioral performance and provide insight on the corresponding neural mechanisms.

Keywords: dopamine; fMRI; functional connectivity; working memory.

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Figures

Figure 1
Figure 1
The effect of bromocriptine on RT slope and accuracy on high-load trials on a delayed recognition task is dependent on working memory span. Data shown represents mean ± SE of the mean. Asterisks indicate p < 0.05; # indicate p < 0.06.
Figure 2
Figure 2
The effect of bromocriptine on fronto-striatal connectivity during performance of a delayed recognition memory task is dependent on working memory span. The mean correlation coefficient (expressed as a z-score) between each pair of regions is indicated alongside each arrow and the thickness of the arrows is scaled proportionally to this value. Asterisk indicates p < 0.05, for significant difference between placebo and drug session, corrected for multiple comparisons.
Figure 3
Figure 3
After bromocriptine administration, changes in frontal–striatal connectivity during the probe period of the delayed recognition task correlated with changes in behavioral performance (RT slope and accuracy on high-load trials).
See this image and copyright information in PMC

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