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Review
. 2011 Sep;10(3):455-61.
doi: 10.1007/s10689-011-9442-1.

Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

A R Latchford  1 , R K S Phillips
Affiliations
Review

Gastrointestinal polyps and cancer in Peutz-Jeghers syndrome: clinical aspects

A R Latchford et al. Fam Cancer. 2011 Sep.

Abstract

The two main problems in the management of the gastrointestinal tract in patients with Peutz-Jeghers syndrome (PJS) are the long term cancer risk and managing polyp related complications, such as intussusception and bleeding. In this article we will focus mainly on the clinical management of these problems. We will highlight some of the controversies regarding gastrointestinal PJS polyps, cancer development and cancer risk. We will review the available literature, particularly focusing on clinical data, to provide insights into these controversies. We describe guidelines for the surveillance and management of gastrointestinal polyps in PJS and review the data behind current recommendations.

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