Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2011 Jun;34(6):1315-7.
doi: 10.2337/dc10-1661. Epub 2011 Apr 19.

Persistence of individual variations in glycated hemoglobin: analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial

Darrell M Wilson  1 , Dongyuan Xing, Jing Cheng, Roy W Beck, Irl Hirsch, Craig Kollman, Lori Laffel, Jean M Lawrence, Nelly Mauras, Katrina J Ruedy, Eva Tsalikian, Howard Wolpert; Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Affiliations
Randomized Controlled Trial

Persistence of individual variations in glycated hemoglobin: analysis of data from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Randomized Trial

Darrell M Wilson et al. Diabetes Care. 2011 Jun.

Abstract

Objective: To determine the individual persistence of the relationship between mean sensor glucose (MG) concentrations and hemoglobin A(1c) (A1C) from the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring (CGM) Randomized Trial.

Research design and methods: MG was calculated using CGM data for 3 months before A1C measurements at 3, 6, 9, and 12 months for the CGM group and at 9 and 12 months for the control group. An MG-to-A1C ratio was included in analysis for subjects who averaged ≥4 days/week of CGM use.

Results: Spearman correlations of the MG-to-A1C ratio between consecutive visits 3 months apart ranged from 0.70 to 0.79. The correlations for children and youth were slightly smaller than those for adults. No meaningful differences were observed by device type or change in A1C.

Conclusions: Individual variations in the rate of hemoglobin glycation are persistent and contribute to the inaccuracy in estimating MGs calculated from A1C levels.

Trial registration: ClinicalTrials.gov NCT00406133.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of the MG-to-A1C ratio from the same subject at different times. The MG-to-A1C ratios of subjects in 3-month periods were compared. The ratio at the earlier time is on the x-axis, and the ratio 3 months later is on the y-axis. Spearman correlation values are given for all four times.
See this image and copyright information in PMC

Comment in

References

    1. American Diabetes Association Standards of clinical practice recommendations—2009. Diabetes Care 2009;32(Suppl. 1):S13–S61 - PMC - PubMed
    1. International Expert Committee International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 2009;32:1327–1334 - PMC - PubMed
    1. American Diabetes Association. Estimated average glucose, eAG [article online], 2009. Available from http://www.diabetes.org/living-with-diabetes/treatment-and-care/blood-gl... Accessed 1 June 2010
    1. Cohen RM, Snieder H, Lindsell CJ, et al. Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1C in nondiabetic twins. Diabetes Care 2006;29:1739–1743 - PubMed
    1. Boland E, Monsod T, Delucia M, Brandt CA, Fernando S, Tamborlane WV. Limitations of conventional methods of self-monitoring of blood glucose: lessons learned from 3 days of continuous glucose sensing in pediatric patients with type 1 diabetes. Diabetes Care 2001;24:1858–1862 - PubMed

Publication types

Associated data