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Clinical Trial
. 2011 Mar;26(4):659-63.
doi: 10.1002/mds.23538.

Modulation of dysarthropneumophonia by low-frequency STN DBS in advanced Parkinson's disease

Caroline Moreau  1 , Odile Pennel-Ployart, Serge Pinto, Audrey Plachez, Agnes Annic, François Viallet, Alain Destée, Luc Defebvre
Affiliations
Clinical Trial

Modulation of dysarthropneumophonia by low-frequency STN DBS in advanced Parkinson's disease

Caroline Moreau et al. Mov Disord. 2011 Mar.

Abstract

Background: Parkinsonian dysarthria (as typically characterized by hypophonia, monotony of pitch, and rhythm abnormalities) is often accompanied by gait disturbances. The long-term effect of subthalamic nucleus deep brain stimulation (STN DBS) on dysarthria remains unclear.

Methods: Given STN DBS's known improvement of gait disorders, we analyzed speech intelligibility and aerodynamic and acoustic parameters in 11 advanced PD patients in three double-blind, randomized conditions: "defined Off," 60 Hz STN DBS and 130 Hz STN DBS.

Results: An improvement in aerodynamic speech parameters during 60 Hz STN DBS was accompanied by significant clinical benefit.

Conclusions: Chronic treatment with low-frequency STN DBS may have a beneficial impact on dysarthropneumophonia, even in advanced PD patients.

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