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. 2011 Jun;97(3):518-21.
doi: 10.1645/GE-2671.1. Epub 2010 Nov 19.

Host mouse strain is not selective for a laboratory adapted strain of Schistosoma mansoni

Walter A Blank  1 , Shi Fan Liu, Jayendra Prasad, Ronald E Blanton
Affiliations

Host mouse strain is not selective for a laboratory adapted strain of Schistosoma mansoni

Walter A Blank et al. J Parasitol. 2011 Jun.

Abstract

We genotyped pooled adult worms of Schistosoma mansoni from infected CF1, C57BL/6, BALB/c, and BALB/c interferon gamma knockout mice in order to establish if mouse strain differences selected for parasite genotypes. We also compared differentiation in eggs collected from liver and intestines to determine if there was differential distribution of parasite strains in the vertebrate host that might account for any genotype selection. We found that mouse strains with differing immune responses did not differ in resistance to infection and did not select for parasite genotypes. Schistosoma mansoni egg allele frequencies were also equally distributed in tissues and the difference between adult and egg allele frequencies was negligible.

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References

    1. Alarcón de Noya B, Pointier JP, Colmenares C, Théron A, Balzan C, Cesari IM, González S, Noya O. Natural Schistosoma mansoni infection in wild rats from Guadeloupe: parasitological and immunological aspects. Acta tropica. 1997;68:11–21. - PubMed
    1. Blank WA, Test MR, Liu SF, Lewis FA, Blanton RE. Long-term genetic stability and population dynamics of laboratory strains of Schistosoma mansoni. Journal of Parasitology. 2010 In Press. - PMC - PubMed
    1. Bremond P, Pasteur N, Combes C, Renaud F, Theron A. Experimental host-induced selection in Schistosoma mansoni strains from Guadeloupe and comparison with natural observations. Heredity. 1993;70:33–37. - PubMed
    1. Colley DG, Freeman GL., Jr Differences in Adult Schistosoma Mansoni Worm Burden Requirements for the Establishment of Resistance to Reinfection in Inbred Mice: I. CBA/J and C57BL/6 Mice. Am J Trop Med Hyg. 1980;29:1279–1285. - PubMed
    1. Dean DA, Bukowski MA, Cheever AW. Relationship between acquired resistance, portal hypertension, and lung granulomas in ten strains of mice infected with Schistosoma mansoni. American Journal of Tropical Medicine and Hygeine. 1981;30:806–814. - PubMed

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