doi: 10.1097/TP.0b013e3182157d44.
Direct pathway T-cell alloactivation is more rapid than indirect pathway alloactivation
- PMID: 21508799
- PMCID: PMC3748592
- DOI: 10.1097/TP.0b013e3182157d44
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Direct pathway T-cell alloactivation is more rapid than indirect pathway alloactivation
Transplantation.
.
No abstract available
Figures
(A) In comparison with CB6F1 donor skin grafts, there is a delay in rejection of BALB/c donor skin grafts by B6.TEa.Rag2−/− recipients (n≥4). (B) Delayed proliferation of B6.TEa.Rag2−/− CD4+ T cells when the alloantigen is presented by the indirect pathway (n=3).
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References
-
- Bolton EM, Bradley JA, Pettigrew GJ. Indirect allorecognition: Not simple but effective. Transplantation. 2008;85:667. - PubMed
-
- Gokmen MR, Lombardi G, Lechler RI. The importance of the indirect pathway of allorecognition in clinical transplantation. Curr Opin Immunol. 2008;20:568. - PubMed
-
- Grubin CE, Kovats S, deRoos P, et al. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 1997;7:197. - PubMed
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