At 17, in-10's passion need not inflame
- PMID: 21511180
- DOI: 10.1016/j.immuni.2011.04.004
At 17, in-10's passion need not inflame
Abstract
In this issue of Immunity, Chaudhry et al. (2011) and Huber et al. (2011) report that control of Th17 cell responses during colonic inflammation requires direct signaling by IL-10 in regulatory T cells and Th17 cells.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.Immunity. 2011 Apr 22;34(4):554-65. doi: 10.1016/j.immuni.2011.01.020. Immunity. 2011. PMID: 21511184 Free PMC article.
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Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.Immunity. 2011 Apr 22;34(4):566-78. doi: 10.1016/j.immuni.2011.03.018. Immunity. 2011. PMID: 21511185 Free PMC article.
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