The role played by the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) activator, GW501516, in control of fatty acid metabolism: a new potential therapeutic target for treating metabolic syndrome
- PMID: 21511987
- DOI: 10.1210/en.2011-0211
The role played by the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) activator, GW501516, in control of fatty acid metabolism: a new potential therapeutic target for treating metabolic syndrome
Comment on
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The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.Endocrinology. 2011 May;152(5):1848-59. doi: 10.1210/en.2010-1468. Epub 2011 Mar 1. Endocrinology. 2011. PMID: 21363937
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