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. 2008;35(4):272-277.
doi: 10.1159/000142333. Epub 2008 Jul 21.

Mesenchymal Stem Cells - Sources and Clinical Applications

Hans Klingemann  1 , David Matzilevich, James Marchand
Affiliations

Mesenchymal Stem Cells - Sources and Clinical Applications

Hans Klingemann et al. Transfus Med Hemother. 2008.

Abstract
in English, German

SUMMARY: Although mesenchymal stem cells (MSC) from different tissue sources share many characteristics and generally fulfill accepted criteria for MSC (plastic adherence, certain surface marker expression, and ability to differentiate into mesenchymal tissues), we are increasingly learning that they can be distinguished at the level of cytokine production and gene expression profiles. Their ability to differentiate into different tissues including endodermal and ectodermal lineages, also varies according to tissue origin. Importantly, MSC from fetal sources can undergo more cell divisions before they reach senescence than MSC from adult tissue such as bone marrow or adipose tissue. As we learn more about the differentiation and plasticity of MSC from different sources, health care providers in the future will use them tailored to different medical indications.

Zusammenfassung: Obwohl aus verschiedenen Geweben stammende mesenchymale Stammzellen (MSC) viele Gemeinsamkeiten aufweisen und im Allgemeinen die für MSC akzeptierten Kriterien erfüllen (plastische Adhäsion, Expression bestimmter Oberflächenmarker sowie Fähigkeit zur Differenzierung in mesenchymale Gewebe), wird immer klarer, dass sich MSC auf der Ebene der Zytokinproduktion und Genexpressionsprofile voneinander unterscheiden. Auch ihre Fähigkeit, in verschiedene Gewebe (inklusive endodermale und ektodermale Zelllinien) zu differenzieren, ist je nach Herkunftsgewebe verschieden. Nennenswerter Weise durchlaufen MSC fötalen Ursprungs mehr Zellteilungen vor Erreichen der Seneszenz als MSC aus adulten Geweben wie Knochenmark oder Fettgewebe. Mit zunehmendem Wissen über ihre Differenzierung und Plastizität werden MSC verschiedenen Ursprungs zukünftig gezielt und auf spezifische Indikationen zugeschnitten in der medizinischen Versorgung eingesetzt werden.

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