Oogenesis: when most is good enough
- PMID: 21514514
- DOI: 10.1016/j.cub.2011.03.010
Oogenesis: when most is good enough
Abstract
In male meiosis an unaligned chromosome blocks meiotic progression. However, oocytes with one or more misaligned chromosomes can complete meiosis. This difference reflects a more permissive role of the spindle assembly checkpoint, rather than solely reflecting the ability of some univalents to adopt a meiosis II-like orientation on the spindle.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Comment on
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Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errors.Curr Biol. 2011 Apr 26;21(8):651-7. doi: 10.1016/j.cub.2011.03.003. Epub 2011 Apr 14. Curr Biol. 2011. PMID: 21497085 Free PMC article.
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