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. 2011 Jun;7(6):348-50.
doi: 10.1038/nchembio.559. Epub 2011 Apr 24.

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Linda Ejim  1 , Maya A Farha, Shannon B Falconer, Jan Wildenhain, Brian K Coombes, Mike Tyers, Eric D Brown, Gerard D Wright
Affiliations

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Linda Ejim et al. Nat Chem Biol. 2011 Jun.

Abstract

Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.

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