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. 2011 Mar 8:2:9.
doi: 10.3389/fneur.2011.00009. eCollection 2011.

Intra-arterial treatment methods in acute stroke therapy

Thanh N Nguyen  1 , Viken L Babikian, Rafael Romero, Aleksandra Pikula, Carlos S Kase, Tudor G Jovin, Alexander M Norbash
Affiliations

Intra-arterial treatment methods in acute stroke therapy

Thanh N Nguyen et al. Front Neurol. .

Abstract

Acute revascularization is associated with improved outcomes in ischemic stroke patients. It is unclear which method of intra-arterial intervention, if any, is ideal. Promising approaches in acute stroke treatment are likely a combination of intravenous and endovascular revascularization efforts, combining early treatment initiation with direct clot manipulation and/or PTA/stenting. In this review, we will discuss available thrombolytic therapies and endovascular recanalization techniques, beginning with chemical thrombolytic agents, followed by mechanical devices, and a review of ongoing trials. Further randomized studies comparing medical therapy, intravenous and endovascular treatments are essential, and their implementation will require the wide support and enthusiasm from the neurologic, neuroradiologic, and neurosurgical stroke communities.

Keywords: angioplasty; aspiration devices; intra-arterial therapy; intra-arterial thrombolysis; mechanical embolectomy; retrieval devices; stent.

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Figures

Figure 1
Figure 1
Merci Retriever V 2.5 series (with permission, Concentrics Medical).
Figure 2
Figure 2
Penumbra microcatheter and separator system (with permission, Penumbra Inc.).
Figure A1
Figure A1
Figure A2
Figure A2
See this image and copyright information in PMC

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