[Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)]
- PMID: 21516785
- DOI: 10.18097/pbmc20115701133
[Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)]
Abstract
In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats.
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