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. 2011 Jan-Feb;57(1):133-7.
doi: 10.18097/pbmc20115701133.

[Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)]

[Article in Russian]

[Synthesis and hypoglycemic activity of bis(L-malato)oxovanadium(IV)]

[Article in Russian]
V K Gorodetskiĭ et al. Biomed Khim. 2011 Jan-Feb.

Abstract

In order to create new oral vanadyl organic complexes-based drugs for the treatment of diabetes mellitus biligand vanadyl derivative of L-malic acid (bis(L-malato)oxovanadium(IV) was prepared and its potential as a novel hypoglycemic agent was studied in the streptozotocin-diabetic rats. We show that the oral administration of bis(L-malato)oxovanadium(IV) with drink water significantly reduced glucose concentration in blood and urine, as well as the level of glycated proteins in the streptozotocin-diabetic rats.

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