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Review
. 2011 Apr 26;123(16):1771-9.
doi: 10.1161/CIRCULATIONAHA.109.858019.

Getting to the heart of myocardial stem cells and cell therapy

Tara L Rasmussen  1 , Ganesh Raveendran, Jianyi Zhang, Daniel J Garry
Affiliations
Review

Getting to the heart of myocardial stem cells and cell therapy

Tara L Rasmussen et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
An emerging hypothesis is that the regeneration potential is linked to the fibroproliferative response of the injured tissue. A) The development of scar following injury results in tissue (cardiac) dysfunction. The ability of an injured heart to regenerate results in improvement of cardiac function. B) Models suggest there is a balance between scar formation and regeneration. These models support the notion that scar formation impairs regeneration and a regenerating tissue lacks scar.
Figure 2
Figure 2
The neonatal and adult mammalian hearts are capable of cellular proliferation. A) Relative cardiomyocyte proliferation from BrdU labeling and tritiated thymidine incorporation studies of neonatal and adolescent mice support the notion that the heart’s proliferative capacity decreases with age (see references # and #35). B) BrdU labeling studies following injury reveal proliferation of murine cardiomyocytes in the border region of the adult mouse heart. Arrowheads mark BrdU labeled cardiomyocyte nuclei, which are green and are immunostained with α-actinin, which is red. Adapted from Naseem et al. Physiol Genomics, 2007. Am Physiol Soc, used with permission.
Figure 3
Figure 3
The adult heart is capable of limited regeneration. A) Schematic highlighting the potential of stem cells for self renewal and their capacity to generate cardiac progenitors or cardiomyocytes. B) Schematic highlighting the possibility that extracardiac stem or progenitors can be recruited from the bone marrow, the endothelial lineage, skeletal muscle or other sources to further participate in myocardial regeneration and repair. C) Table outlining several cardiac stem or progenitors that have been identified and their characterization. E: embryonic expression; A: adult expression.
See this image and copyright information in PMC

References

    1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J. Heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. 2010;121:e46–e215. - PubMed
    1. Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM. Necl2 regulates epidermal adhesion and wound repair. Development. 2009;136:3505–3514. - PMC - PubMed
    1. Goetsch SC, Hawke TJ, Gallardo TD, Richardson JA, Garry DJ. Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration. Physiol Genomics. 2003;14:261–271. - PubMed
    1. Gennero L, Roos MA, Sperber K, Denysenko T, Bernabei P, Calisti GF, Papotti M, Cappia S, Pagni R, Aimo G, Mengozzi G, Cavallo G, Reguzzi S, Pescarmona GP, Ponzetto A. Pluripotent plasticity of stem cells and liver repopulation. Cell Biochem Funct. 2010;28:178–189. - PubMed
    1. Menthena A, Deb N, Oertel M, Grozdanov PN, Sandhu J, Shah S, Guha C, Shafritz DA, Dabeva MD. Bone marrow progenitors are not the source of expanding oval cells in injured liver. Stem Cells. 2004;22:1049–1061. - PubMed

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