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Review
. 2011 Jun;7(6):701-11.
doi: 10.4161/hv.7.6.15398. Epub 2011 Jun 1.

Filovirus vaccines

Steven B Bradfute  1 , John M Dye Jr, Sina Bavari
Affiliations
Review

Filovirus vaccines

Steven B Bradfute et al. Hum Vaccin. 2011 Jun.

Abstract

Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses. A variety of vaccine platforms have been shown to be effective against filovirus infection. This review summarizes the literature in this field, focusing on vaccines that have been shown to protect NHPs from infection. Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed.

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