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Review
. 2011 Jul;18(4):266-72.
doi: 10.1097/MOH.0b013e3283476012.

Role of microRNAs in lymphoid biology and disease

Muller Fabbri  1 , Carlo M Croce
Affiliations
Review

Role of microRNAs in lymphoid biology and disease

Muller Fabbri et al. Curr Opin Hematol. 2011 Jul.

Abstract

Purpose of review: This review provides a state-of-the-art knowledge on the implications of microRNA (miRNA) dysregulation in lymphoid malignancies.

Recent findings: Several new studies have broadened our understanding of how aberrations of the miRNome contribute to the development of a malignant lymphoid phenotype. Recently, a new pathogenetic model involving miRNAs and protein coding genes (such as TP53 and ZAP-70) has been identified and explains the prognostic implications of the most recurrent chromosomal abnormalities in human B-cell chronic lymphocytic leukemia. Moreover, new recent studies have addressed the role of miRNAs in human lymphomas and acute lymphoblastic leukemias.

Summary: The recent advances in our understanding of the role of miRNAs in lymphoid malignancies demonstrate that miRNAs can effectively be used as tumoral biomarkers with implications for diagnosis, prognosis, and prediction of response to therapy.

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Figures

Figure 1
Figure 1. A network involving miRNAs and Protein Coding Genes is involved in B-CLL pathogenesis and can explain the prognostic implications of the most recurrent chromosomal abnormalities in B-CLL
A. In CLL with normal cytogenetics, the miR-15a/16-1 cluster (located at 13q) is transactivated by TP53 (on chromosome 17p) and directly silences this tumor suppressor gene. TP53 can also transactivate the miR-34b/34c cluster (located at 11q), which directly target the surrogate prognostic marker ZAP-70. B. In CLL carrying the 13q deletion (the most common chromosomal abnormality), the miR-15a/16-1 cluster is absent because of the deletion, which releases TP53 from the inhibitory control by the cluster. High levels of TP53, activate the expression of the miR-34b/34c cluster, which targets ZAP-70 and reduces the expression of this tumoral marker.
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