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. 2011 Mar;19(1):26-31.
doi: 10.4250/jcu.2011.19.1.26. Epub 2011 Mar 31.

Correlation between N-Terminal Pro-Brain Natriuretic Peptide and Doppler Echocardiographic Parameters of Left Ventricular Filling Pressure in Atrial Fibrillation

Woo Shin Kim  1 , Seong-Hoon Park
Affiliations

Correlation between N-Terminal Pro-Brain Natriuretic Peptide and Doppler Echocardiographic Parameters of Left Ventricular Filling Pressure in Atrial Fibrillation

Woo Shin Kim et al. J Cardiovasc Ultrasound. 2011 Mar.

Abstract

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia with a population prevalence of about 1%. Natriuretic peptide level is elevated in patients with AF with diastolic dysfunction even with a normal left ventricular (LV) ejection fraction. The N-terminal pro-brain natriuretic peptide (NT-proBNP) level and Doppler echocardiographic parameters for diastolic function have shown correlation with LV filling pressures. We aimed to evaluate the relationship between echocardiographic parameters and serum NT-proBNP in patients with AF with preserved LV ejection fraction.

Methods: We examined transthoracic echocardiography and NT-proBNP levels in the patients with AF and patients with sinus rhythm. Blood samples were taken for serum NT-proBNP measurements within 24 hours of echocardiographic examination. The group 1 was the patients with sinus rhythm (n = 30, mean age 68 ± 13 years) and the group 2 was the patients with AF (n = 33, mean age 70 ± 14 years).

Results: The group 2 patients had significantly higher mitral E, E' (lateral annulus), E/E' (septal annulus), left atrial (LA) volume index, LA size, pulmonary vein diastolic velocity, and NT-proBNP level than those of group 1 patients (p < 0.05). The area under the receiver-operating characteristic curve showed a NT-proBNP had good diagnostic power for E/E' (septal annulus) > 15 in patients with AF at cutoff value of 433 pg/mL.

Conclusion: NT-proBNP level is well correlated with Doppler echocardiographic parameters of diastolic function in patients with AF and preserved LV ejection fraction. NT-proBNP level more than 433 pg/mL may suggest elevated LV filling pressure in patients with AF.

Keywords: Atrial fibrillation; Doppler echocardiography; NT-proBNP.

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Figures

Fig. 1
Fig. 1
Scatter plots showing the correlation between plasma NT-proBNP level and Mitral E (A), left atrial volume index (B), left atrial size (C), PVs (D), PVd (E), and PVs/PVd (F). Group 1: patients with normal sinus rhythm, manifested by ●, Group 2: patients with atrial fibrillation, manifested by ▲. NT-proBNP: N-terminal pro-brain natriuretic peptide, PVs: pulmonary vein systolic velocity, PVd: pulmonary vein diastolic velocity, PVs/PVd: ratio of PVs/PVd.
Fig. 2
Fig. 2
ROC curve for NT-proBNP value of 433 pg/mL in prediction of E/E' (septal annulus) > 15 in patients with atrial fibrillation. ROC: receiver operating characteristic, NT-proBNP: N-terminal pro-brain natriuretic peptide.
See this image and copyright information in PMC

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References

    1. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention. The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001;285:2370–2375. - PubMed
    1. Bakowski D, Wozakowska-Kaplon B, Opolski G. The influence of left ventricle diastolic function on natriuretic peptides levels in patients with atrial fibrillation. Pacing Clin Electrophysiol. 2009;32:745–752. - PubMed
    1. Oki T, Tabata T, Yamada H, Wakatsuki T, Fukuda K, Abe M, Onose Y, Iuchi A, Fukuda N, Ito S. Evaluation of left atrial filling using systolic pulmonary venous flow velocity measurements in patients with atrial fibrillation. Clin Cardiol. 1998;21:169–174. - PMC - PubMed
    1. Nagueh SF, Mikati I, Kopelen HA, Middleton KJ, Quiñones MA, Zoghbi WA. Doppler estimation of left ventricular filling pressure in sinus tachycardia: A new application of tissue Doppler imaging. Circulation. 1998;98:1644–1650. - PubMed
    1. Seino Y, Ogawa A, Yamashita T, Fukushima M, Ogata K, Fukumoto H, Takano T. Application of NT-proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure. Eur J Heart Fail. 2004;6:295–300. - PubMed