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. 2011 Jun 7;47(21):6054-6.
doi: 10.1039/c1cc11465d. Epub 2011 Apr 26.

Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

Yasutaka Anraku  1 , Akihiro Kishimura, Atsushi Kobayashi, Makoto Oba, Kazunori Kataoka
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Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

Yasutaka Anraku et al. Chem Commun (Camb). .

Abstract

Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (∼150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.

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