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Randomized Controlled Trial
. 2012 Apr;34(2):507-17.
doi: 10.1007/s11357-011-9247-z. Epub 2011 Apr 26.

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

Vincenzo Solfrizzi  1 , Emanuele Scafato, Vincenza Frisardi, Daniele Sancarlo, Davide Seripa, Giancarlo Logroscino, Marzia Baldereschi, Gaetano Crepaldi, Antonio Di Carlo, Lucia Galluzzo, Claudia Gandin, Domenico Inzitari, Stefania Maggi, Alberto Pilotto, Francesco Panza; Italian Longitudinal Study on Aging Working Group
Collaborators, Affiliations
Randomized Controlled Trial

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

Vincenzo Solfrizzi et al. Age (Dordr). 2012 Apr.

Abstract

Cognition has already been considered as a component of frailty, and it has been demonstrated that it is associated with adverse health outcomes. We estimated the prevalence of frailty syndrome in an Italian older population and its predictive role on all-cause mortality and disability in nondemented subjects and in demented patients. We evaluated 2,581 individuals recruited from the Italian Longitudinal Study on Aging, a population-based sample of 5,632 subjects, aged 65-84 years old. Participants received identical baseline evaluation at the 1st survey (1992-1993) and were followed at 2nd (1995-1996) and 3rd survey (2000-2001). A phenotype of frailty according to partially modified measurement of Cardiovascular Health Study criteria was operationalized. The overall prevalence of frailty syndrome in this population-based study was 7.6% (95% confidence interval (CI) 6.55-8.57). Frail individuals noncomorbid or nondisable were 9.1% and 39.3%, respectively, confirming an overlap but not concordance in the co-occurrence among these conditions. Frailty was associated with a significantly increased risk of all-cause mortality over a 3-year follow-up (hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.52-2.60) and over a 7-year follow-up (HR 1.74, 95% CI 1.44-2.16), but with significant increased risk of disability only over a 3-year follow-up (HR 1.32, 95% CI 1.06-1.86 over a 3-year follow-up and HR 1.16, 95% CI 0.88-1.56 over a 7-year follow-up). Frail demented patients were at higher risk of all-cause mortality over 3- (HR 3.33, 95% CI 1.28-8.29) and 7-year follow-up periods (HR 1.89, 95% CI 1.10-3.44), but not of disability. Frailty syndrome was a short-term predictor of disability in nondemented older subjects and short- and long-term predictor of all-cause mortality in nondemented and demented patients.

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Figures

Fig. 1
Fig. 1
Attrition of the study population at the different phases of the survey, Italian Longitudinal Study on Aging, 1992–1993. BMI body mass index, ADL Activities of Daily Living, IADL Instrumental Activities of Daily Living, CHS Cardiovascular Health Study
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References

    1. Diagnostic and statistical manual of mental disorders, 3rd edn, revised (DSM-III-R) Washington, DC: American Psychiatric Association; 1987. pp. 103–107.
    1. Avila-Funes JA, Helmer C, Amieva H, Barberger-Gateau P, Goff M, Ritchie K, Portet F, Carrière I, Tavernier B, Gutiérrez-Robledo LM, Dartigues JF. Frailty among community-dwelling elderly people in France: the Three-City Study. J Gerontol A Biol Sci Med Sci. 2008;63:1089–1096. doi: 10.1093/gerona/63.10.1089. - DOI - PMC - PubMed
    1. Avila-Funes JA, Amieva H, Barberger-Gateau P, Goff M, Raoux N, Ritchie K, Carrière I, Tavernier B, Tzourio C, Gutiérrez-Robledo LM, Dartigues JF. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the Three-City Study. J Am Geriatr Soc. 2009;57:453–461. doi: 10.1111/j.1532-5415.2008.02136.x. - DOI - PubMed
    1. Aziz NA, Marck MA, Pijl H, Olde Rikkert MG, Bloem BR, Roos RA. Weight loss in neurodegenerative disorders. J Neurol. 2008;255:1872–1880. doi: 10.1007/s00415-009-0062-8. - DOI - PubMed
    1. Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, Zeger SL, Fried LP. Phenotype of frailty: characterization in the women’s health and aging studies. J Gerontol A Biol Sci Med Sci. 2006;61:262–266. doi: 10.1093/gerona/61.3.262. - DOI - PubMed

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