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Comment
. 2011 Apr 28;70(2):171-2.
doi: 10.1016/j.neuron.2011.04.008.

A new, blue gene highlights glutamate and hippocampus in depression

Heike Tost  1 , Andreas Meyer-Lindenberg
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Free article
Comment

A new, blue gene highlights glutamate and hippocampus in depression

Heike Tost et al. Neuron. .
Free article

Abstract

Depression is a common and debilitating psychiatric syndrome with a complex risk architecture marked by interacting genetic and environmental factors. In this issue of Neuron, the study by Kohli et al. (2011) reports a novel genome-wide supported risk variant for depression that affects hippocampal gene expression, anatomy, and biochemistry.

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  • The neuronal transporter gene SLC6A15 confers risk to major depression.
    Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB. Kohli MA, et al. Neuron. 2011 Apr 28;70(2):252-65. doi: 10.1016/j.neuron.2011.04.005. Neuron. 2011. PMID: 21521612 Free PMC article.

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