Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan 8;67(Pt 2):o308-9.
doi: 10.1107/S1600536810054048.

1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one

Margarita Gutierrez, Luis Astudillo, Luisa Quesada, Iván Brito, Matías López-Rodríguez

1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one

Margarita Gutierrez et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

The title compound, (I) C(28)H(24)N(4)O(4), is the trans diastereo-isomer of the compound 1-[2-(4-nitro-phen-yl)-6-(5-phenyl-3-isoxazol-yl)-1,2,3,4-tetra-hydro-4-quinolin-yl]-2-pyrrolidinone monohydrate, (II) [Gutierrez et al. (2011 ▶). Acta Cryst. E67, o175-o176]. The most obvious differences between the diastereo-isomers are the dihedral angles between the isoxazole ring and the benzene and phenyl rings [47.0 (2); 56.4 (2) and 33.3 (2); 11.0 (2)°, respectively, for (II) 75.4 (2) and 5.8 (3), respectively, for (I)]. In the crystal of (I), the mol-ecules are linked by N-H⋯O inter-actions into a chain along [001] with graph-set notation C(8).

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
The structure of (I), showing the atom-numbering scheme. Displacement ellipsoids are plotted at the 30% probability level.
Fig. 2.
Fig. 2.
A view of (I), showing the mono-dimensional framework constructed via N—H···O hydrogen bonds. Hydrogen bonds are depicted as dashed lines [symmetry-code:(i) y, -x + y, z - 1/6.]
Fig. 3.
Fig. 3.
The preparation of the title compound.
See this image and copyright information in PMC

References

    1. Altomare, A., Burla, M. C., Camalli, M., Cascarano, G. L., Giacovazzo, C., Guagliardi, A., Moliterni, A. G. G., Polidori, G. & Spagna, R. (1999). J. Appl. Cryst. 32, 115–119.
    1. Bernstein, J., Davis, R. E., Shimoni, L. & Chang, N.-L. (1995). Angew. Chem. Int. Ed. Engl. 34, 1555–1573.
    1. Broggini, G., Chiesa, K., De Marchi, I., Martinelli, M., Pilati, T. & Zecchi, G. (2005). Tetrahedron, 61, 3525–3531.
    1. Cremer, D. & Pople, J. A. (1975). J. Am. Chem. Soc. 97, 1354–1358.
    1. Eswaran, S., Adhikari, V. A., Pal, K. N. & Chowdhury, H. I. (2010). Bioorg. Med. Chem. 20, 1040–1044. - PubMed